The first trailer for Dallas Buyers Club has finally hit the web. This is the movie that gave us all those photos (last year) of a stick-thin Matthew McConaughey. The actor lost nearly 50 pounds to portray Ron Woodroof, a Texas man who was diagnosed with HIV in 1986, leading him to smuggle effective but illegal drugs from Mexico into the United States to help patients like himself. Watch the trailer below.

McConaughey has been getting a lot of buzz for his performance in this drama. It’ll be nice to see him get a  likely Oscar nomination, especially because, lately, he’s been working his butt off and seems to get no recognition from the Academy.

However, he doesn’t seem to be the only actor worth watching in this movie. The brand new trailer also gives us a glimpse of Jared Leto, who just as riveting in drag. The actor/singer plays a transsexual woman named Rayon, who becomes Woodroof’s fellow patient and partner in the Dallas Buyers Club. Leto, who slimmed down to a shocking 116 pounds, is hardly recognizable.

Here’s the trailer:

From writers Craig Borten and Melisa Wallack, Dallas Buyers Club will have it’s world premiere at the 2013 Toronto Film Festival. The film will be in theaters November 1st, hitting New York and Los Angeles first.

What do you think of the trailer? Are you intrigued by the performances?

[via Cinemablend]