The cast and crew of Resident Evil: Retribution held court in the hallowed Hall H of Comic-Con 2012 today discussing what is the fifth film in a series of video game adaptations from the director of Mortal Kombat and Alien vs. PredatorWelcome to the most depressing panel of your 2012 Comic-Con.

Featuring director Paul W.S. Anderson, his wife and star Milla Jovovich, and co-stars Michelle Rodriquez, Oded Fehr, Boris Kodjoe and Mika Nakashima, the panel opened with the 3D version of the film’s theatrical trailer, which had premiered one day earlier at Comic-Con’s Trailer Park.

Anderson noted that with Resident Evil: Retribution, he needed to “make the franchise much bigger” as he hinted that it is finally coming to an end.  Hence, the 3D, the globe-trotting (the zombie movie features action scenes in Tokyo, Moscow, Washington D.C., and Manhattan), and the supposedly nine minute fight on top of a glacier that closes the film:

“We really wanted to blow out the franchise and make it much bigger for the fans who have been kind of sticking with us.  We really feel the franchise is reaching a climax, and we wanted to make this an epic. I wanted to make the first truly post-apocalyptic film.”

I’ll go ahead and let you do a spit-take at Anderson saying that Resident Evil: Retribution is the first post-apocalyptic film (forgetting, oh, say, Escape From New York, The Road Warrior, 12 Monkeys, the Terminator franchise, etc), before moving on.

Later, Jovovich noted that playing her long-suffering protagonist as a regular woman with a family before the franchise’s zombie outbreak (in previous installments, we only see her a zombie killing badass; in this film, she is implanted with false memories of a zombie-less life) gave her perspective on the character:

“It was horrifying, because to be honest, I didn’t really appreciate what it was like to be a superhero until I played a normal person within the `Resident Evil’ world, and normal people really have it bad.  They just run and scream and get killed horrifically.”

It was also a difficult transition from her usual routine of blankly firing guns at things:

“Screaming and being suburban Alice, that was the worst part of the movie. I would have such a headache. It’s so much easier just to have a machine gun, a cool outfit, blow them away then walk off looking really rad.”

As opposed to, you know, acting and stuff.

Later, a two-minute clip of the film’s ten-minute climax was shown, in which “Rodriguez’s character spits bullets out of her fingertips!”

Hey, they can’t all be Citizen Kane, guys.

Resident Evil: Retribution opens on September 14.

Will you be seeing the newest Resident Evil film?

Sources: Cinema Blend and The Huffington Post