Nora Ephron, three-time Academy Award nominee for Best Original Screenplay (Silkwood, When Harry Met Sally…, and Sleepless in Seattle), died at the age of 71 on Tuesday for as-yet undisclosed reasons.  Friends and family have spoken out that Ephron had been suffering from leukemia as details continue to emerge.

Born to playwrights Henry and Phoebe Ephron, Ephron scored her first Academy Award nomination with her screenplay for Silkwood, a Meryl Streep vehicle concerning the true story of Karen Silkwood, a woman who died mysteriously while investigating wrongdoing at plutonium plant.  The remainder of her screenwriting and directing career tended to consist of lightweight but popular romantic comedy fare:  When Harry Met Sally…, Sleepless in Seattle, Michael, You’ve Got Mail, and the Bewitched film remake.

Ephron’s final film was the time-skipping foodie film, Julie & Julia, which starred Amy Adams and Meryl Streep.

Ephron was also a novelist of considerable power, with her angry novel Heartburn being inspired by true events—the collapse of her marriage to Watergate investigative reporter Carl Bernstein after she discovered his infidelities.   The marriage ended in an acrimonious divorce; the book was adapted into a film starring Jack Nicholson and Meryl Streep.

Ephron is survived by her third and final husband, Nicholas Pileggi (writer of Goodfellas), and her two sons with Carl Bernstein.

What is your favorite Nora Ephron film?