Ron Howard has decided to step away from his mystery driven, religious epics to tackle some lighter fare. According to Variety, the award winning director will join forces with funny man Vince Vaughn for his latest feature. The film is currently untitled, but will be produced by Imagine Entertainment and Universal Pictures.

Vaughn will star and co-produce the film that will be based off an Allan Loeb script. The story will center on infidelity between lovers and friends, which vaguely sounds like the plot from Couples Retreat. Both Howard and Vaughn’s deals are being finalized, but the film’s already scheduled to start shooting in Chicago. Loeb previously wrote the screenplay’s for 21 and the upcoming Oliver Stone sequel, Wall Street 2: Money Never Sleeps.

Ron Howard has done it all, so there’s no doubt that he can handle a comedy but a Vince Vaughn comedy is a different kind of monster. The actor will be producing the flick with his Wild West Picture Show banner, which means he’ll have some serious input. It’s hard for me to fathom those two on the same wavelength when it comes to what joke works and what doesn’t. But then again, didn’t Ron Howard pop up in a Jamie Foxx video not too long ago? Maybe he has a wild side that we have yet to see come out on film?

What do you think of the combo of Howard and Vaughn? Do you think they’ll make a hit or a bomb?