This week, Judd Apatow‘s Funny People hits theaters, and since Harry Potter has already been knocked off the number one spot, it seems like there is no doubt that Apatow will dominate the box office.

Last week, G-Force took the number one spot making over $30 million on its opening weekend, while Harry Potter and the Half Blood Prince came in second, grossing $29.5 million. It was a surprise to see Harry Potter off the top so fast, but perhaps the opening of Harry Potter on IMAX this week will boost ticket sales. Regardless, if the wizards make more or not with the help of IMAX, Funny People has a good chance of making the most and knocking the kid-flick G-Force off the top of the chart.

Apatow’s first feature film The 40 Year Old Virgin was successful in the box office making $21.4 million and ranking at number one. His second film Knocked Up didn’t hit the very top, but it did make more than the first one on opening weekend — $30.7 million.

Funny People stars Adam Sandler, Seth Rogen and Leslie Mann, not to mention a number of other successful co-stars. Adam Sandler has dominated the box office in the past one too many times. In 2007, I Now Pronounce You Chuck and Larry (despite the fact that it was absolute crap) grossed $34.2 million, in 2006, Click grossed over $40 million, and in 2004, 50 First Dates grossed $39.9 million on opening weekend. So as you can see, Sandler hold a good record for dominating the box office and this weekend seems like more of the same.

Also, opening this week are Aliens In the Attic, about a group of kids who set out to protect their vacation home from gooey green aliens, Adam starring Hugh Dancy as a young man with Asperges who falls in love with the woman of his dreams, The Collector, and The Cove, an amazing documentary dealing with the dolphin killings that occur every year in Japan. All of these films are set for limited release and don’t stand a chance in hell against the Sandler/Rogen/Apatow driven comedy Funny People.

This weekend belongs to Apatow and his comedic cast, we’re sure. So the question is, how much will it make?

Will it be able to break Apatow’s last opening weekend of $30.7 and Sandler’s latest opening weekend $34.2? So far, people have no been running out to theaters and people are unsure about it’s premise — a comedian dying and forcing another comedian to be his friend.

My guess, it comes it just under $30 million.

What do you think? Over or under?